Hairs are the appendages of the skin generated from the
epidermal layer. Hair is a made up of keratin a highly insoluble and
mechanically stable fibrous protein. This keratin is not only found in hairs
but also in the skin. Actually keratin is produced from the keratinization zone
of the epidermis, which is the outer most layer of the skin. In the skin it
provides water proofing quality.
The keratin is generally pigmented. It is intensively
pigmented in the hair. The dark colour of the hair is due to the presence of
high concentration of melanin pigments in it. The skin colour is also due to
the presence of this pigment in the keratinocytes. The keratin gets its melanin
pigments from melanocytes, which found in the inner layer of the epidermis,
which is found just beneath the keratinizing layer. The melanocytes gave long
processes which extent between and under the cells of the epidermis. The melanin
granules formed in the melanocytes pass along their branches and are secreted
at their tips. The granules are subsequently engulfed by the keratinocytes,
which make up 90 per cent of the epidermal cells.
Melanin is a protein like polymer of the amino acid tyrocin.
In its biosynthesis tyrocin is converted into dihydroxy phenyl alanine (DHPA)
by oxidative enzymes amongst which tyrocin is particularly important. Then a
series of reactions take place during which polymerization occurs to form the
final melanoprotein.
The hair grows only from the keratinocytes of the germinal
matrix of the hair follicle. This germinal matrix lies in the proximal
enlargement of the root hair, called the hair bulb. The hair shaft, which
projects from the surface, consists of an inner medulla, an intermediate cortex
and an outer cuticle. All these parts are made up of cornified cells.
The medulla is composed of polyhedral cells; the cortex
consists of elongated cells with inner lumen. These cells are united to form
flattened fusiform fibres. The lumens of these cells contain pigmented granules
in dark hair and air space in white hair.
The development of white hairs because of the absence of
melanin pigments, may be due to the absence of one or more enzymes, necessary
for the DHPA path way. It will lead to the failure of melanin accumulation in
the keratinocytes, found in the hair bulb, from which hair is growing. Usually such
physiological disorder occurs in the old age, which results in the growing of
gray and white hairs in the body.Courtesy : The Hindu.