Why do doctors prescribe some medicines to be taken before and some after food?

When we take a medication, it is absorbed from various parts of our gut — some get absorbed in the stomach, some pass through the stomach into the intestines and get absorbed there.

The most important reason for timing a medication that is taken orally is to maximise its absorption so that more of the medication goes through the stomach into the blood.

Many medicines get absorbed better when food is not present and hence are taken on an empty stomach (an example is the hormone thyroxine which must be taken first thing in the morning). A few actually get absorbed better when food is present — an example of this is the antibiotic azithromycin. Some drugs are taken specifically with or after food because this may reduce the side effects of the drug on the stomach.

For example pain medications and certain antibiotics all can irritate the lining of the stomach and therefore are best taken with or after food. Some drugs work in the wall of the stomach to reduce the absorption of food and this is the desired therapeutic effect — an example of this is the anti-diabetic drug called acarbose.

This drug must be taken with the first bite of food. Similarly other oral anti-diabetic drugs and the injection insulin are taken before food because that is when they need to act — just after you eat a meal. The long and short of it is that the timing of a drug has important effects on its absorption, action, potency and even side effects and it is a good idea not to leave the doctor's office without being sure when you should be taking your medicine. Courtesy : The Hindu